Publications

Sam Margolis publishes scholarly work under Samuel Margolis and Samuel J. Margolis.

Selected

• DrugTargetWorld: A Synthetic Biobank for Training and Benchmarking AI Scientists
  Samuel Margolis, Paul Schmiedmayer, Alan Huang, Ethan Chen, Ishan Bhattacharjee, Atman Shah, Ben Viggiano, Fang Cao, Shriya Reddy, Roger Xia, Jack O'Sullivan, Daniel Katz, Matthew Wheeler, Euan Ashley, Bruna Gomes
  arXiv, 2026 — doi · arXiv · code · data · site · project
• Triage and Referral Behavior Across Patient-Facing Medical AI Products
  Samuel J. Margolis, Naga Venkata Sai Krishna Maddipatla, Kimon L.H. Ioannides, Lauren E. Wisk, David L. Schriger, Joann G. Elmore
  medRxiv, 2026 — doi · project
• Patient-reported outcomes in clinical trials leading to breast cancer drug approvals: are we making them count?
  Samuel Margolis, Andre Naguib Guirguis, Catherine Lee, Saiya Smith, Alexis LeVee, Marla D. Lipsyc-Sharf, Aditya Bardia, Mina S. Sedrak
  Breast Cancer Research and Treatment, 2026 — doi · pubmed
• Benchmarking proprietary and open-source language and vision-language models for gastroenterology clinical reasoning
  Seyed Amir Ahmad Safavi-Naini, Shuhaib Ali, Omer Shahab, Zahra Shahhoseini, Thomas Savage, Sara Rafiee, Jamil S. Samaan, Reem Al Shabeeb, Farah Ladak, Jamie O. Yang, Juan Echavarria, Sumbal Babar, Aasma Shaukat, Samuel Margolis, Nicholas P. Tatonetti, Girish Nadkarni, Bara El Kurdi, Ali Soroush
  npj Digital Medicine, 2025 — doi · pubmed · arXiv · code
• Rapid prediction of acute thrombosis via nanoengineered immunosensors with unsupervised clustering for multiple circulating biomarkers
  Kaidong Wang, Shaolei Wang, Samuel Margolis, Jae Min Cho, Enbo Zhu, Alexander Dupuy, Junyi Yin, Seul-Ki Park, Clara E. Magyar, Oladunni B. Adeyiga, Kristin Schwab Jensen, John A. Belperio, Freda Passam, Peng Zhao, Tzung K. Hsiai
  Science Advances, 2024 — doi · pubmed
• Scalable and stretchable 1D multifunctional fibers for multimodal sensing and stimulation
  Junyi Yin, Jinjin Zhu, Shaolei Wang, Jiangnan Yuan, Chenyang Li, Samuel Margolis, Hong Bao, Yanan Wang, Wei Zhao, Enbo Zhu, Longlong Mu, Shuai He, Kaidong Wang, Jie Zhao, YongAn Huang, Yunlei Zhou
  Nature Communications, 2026 — doi · pubmed

All publications

2026

• DrugTargetWorld: A Synthetic Biobank for Training and Benchmarking AI Scientists
  Samuel Margolis, Paul Schmiedmayer, Alan Huang, Ethan Chen, Ishan Bhattacharjee, Atman Shah, Ben Viggiano, Fang Cao, Shriya Reddy, Roger Xia, Jack O'Sullivan, Daniel Katz, Matthew Wheeler, Euan Ashley, Bruna Gomes
  arXiv, 2026 — doi · arXiv · code · data · site · project
• Triage and Referral Behavior Across Patient-Facing Medical AI Products
  Samuel J. Margolis, Naga Venkata Sai Krishna Maddipatla, Kimon L.H. Ioannides, Lauren E. Wisk, David L. Schriger, Joann G. Elmore
  medRxiv, 2026 — doi · project
• Patient-reported outcomes in clinical trials leading to breast cancer drug approvals: are we making them count?
  Samuel Margolis, Andre Naguib Guirguis, Catherine Lee, Saiya Smith, Alexis LeVee, Marla D. Lipsyc-Sharf, Aditya Bardia, Mina S. Sedrak
  Breast Cancer Research and Treatment, 2026 — doi · pubmed
• Early discontinuation of chemotherapy in older adults with early breast cancer: results from the prospective multicenter HOPE study
  Jingran Ji, Can-Lan Sun, William Dale, Harvey Jay Cohen, Heeyoung Kim, Vani Katheria, Nikita Baclig, Yuliya Zektser, Arman Niknafs, Samuel Margolis, Catherine Lee, Clarie Smith, Mina S Sedrak
  Journal of the National Cancer Institute, 2026 — doi · pubmed
• Scalable and stretchable 1D multifunctional fibers for multimodal sensing and stimulation
  Junyi Yin, Jinjin Zhu, Shaolei Wang, Jiangnan Yuan, Chenyang Li, Samuel Margolis, Hong Bao, Yanan Wang, Wei Zhao, Enbo Zhu, Longlong Mu, Shuai He, Kaidong Wang, Jie Zhao, YongAn Huang, Yunlei Zhou
  Nature Communications, 2026 — doi · pubmed

2025

• Benchmarking proprietary and open-source language and vision-language models for gastroenterology clinical reasoning
  Seyed Amir Ahmad Safavi-Naini, Shuhaib Ali, Omer Shahab, Zahra Shahhoseini, Thomas Savage, Sara Rafiee, Jamil S. Samaan, Reem Al Shabeeb, Farah Ladak, Jamie O. Yang, Juan Echavarria, Sumbal Babar, Aasma Shaukat, Samuel Margolis, Nicholas P. Tatonetti, Girish Nadkarni, Bara El Kurdi, Ali Soroush
  npj Digital Medicine, 2025 — doi · pubmed · arXiv · code
• Refractive index-corrected light-sheet microscopy for macro-view cardiovascular imaging
  Enbo Zhu, Yaran Zhang, Peng Zhao, Jae Min Cho, Zhaoqiang Wang, Yan-Ruide Li, Jing Wang, Samuel Margolis, Shaolei Wang, Lili Yang, Alison Chu, Yuhua Zhang, Liang Gao, Tzung K. Hsiai
  Advanced Science, 2025 — doi · pubmed
• Improving the readability of institutional heart failure–related patient education materials using GPT-4: observational study
  Ryan C. King, Jamil S. Samaan, Joseph Haquang, Vishnu Bharani, Samuel Margolis, Nitin Srinivasan, Yuxin Peng, Yee Hui Yeo, Roxana Ghashghaei
  JMIR Cardio, 2025 — doi · pubmed · preprint
• Sprayable nanocomposite hydrogel dressing enriched with cerium oxide nanoparticles for accelerated wound healing and infection control
  Shichang Liu, Samuel Margolis, Yucheng Zhang, Shaolei Wang, Yan Yu
  Rare Metals, 2025 — doi
• Generating seamless virtual immunohistochemical whole slide images with content and color consistency
  Sitong Liu, Kechun Liu, Samuel Margolis, Wenjun Wu, Stevan R. Knezevich, David E. Elder, Megan M. Eguchi, Joann G. Elmore, Linda G. Shapiro
  IEEE International Symposium on Biomedical Imaging (ISBI), 2025 — doi
• GPT-4 enhances readability of online patient materials for cardiac amyloidosis
  Joseph Haquang, Vishnu Bharani, Jamil S. Samaan, Ryan C. King, Samuel Margolis, Nitin Srinivasan, Nithya D. Rajeev, Joshua Chan, Yee Hui Yeo, Roxana Ghashghaei
  medRxiv, 2025 — doi

2024

• Vision-language and large language model performance in gastroenterology: GPT, Claude, Llama, Phi, Mistral, Gemma, and quantized models
  Seyed Amir Ahmad Safavi-Naini, Shuhaib Ali, Omer Shahab, Zahra Shahhoseini, Thomas Savage, Sara Rafiee, Jamil S Samaan, Reem Al Shabeeb, Farah Ladak, Jamie O Yang, Juan Echavarria, Sumbal Babar, Aasma Shaukat, Samuel Margolis, Nicholas P Tatonetti, Girish Nadkarni, Bara El Kurdi, Ali Soroush
  arXiv, 2024 — doi · published version
• GPT-4 improves readability of institutional heart failure patient education materials: an observational study
  Ryan C. King, Jamil S. Samaan, Joseph Haquang, Vishnu Bharani, Samuel Margolis, Nitin Srinivasan, Yuxin Peng, Yee Hui Yeo, Roxana Ghashghaei
  medRxiv, 2024 — doi · published version
• Rapid prediction of acute thrombosis via nanoengineered immunosensors with unsupervised clustering for multiple circulating biomarkers
  Kaidong Wang, Shaolei Wang, Samuel Margolis, Jae Min Cho, Enbo Zhu, Alexander Dupuy, Junyi Yin, Seul-Ki Park, Clara E. Magyar, Oladunni B. Adeyiga, Kristin Schwab Jensen, John A. Belperio, Freda Passam, Peng Zhao, Tzung K. Hsiai
  Science Advances, 2024 — doi · pubmed
• Non-invasive detection of early-stage fatty liver disease via an on-skin impedance sensor and attention-based deep learning
  Kaidong Wang, Samuel Margolis, Jae Min Cho, Shaolei Wang, Brian Arianpour, Alejandro Jabalera, Junyi Yin, Wen Hong, Yaran Zhang, Peng Zhao, Enbo Zhu, Srinivasa Reddy, Tzung K. Hsiai
  Advanced Science, 2024 — doi · pubmed
• Frontiers in artificial intelligence-directed light-sheet microscopy for uncovering biological phenomena and multiorgan imaging
  Enbo Zhu, Yan-Ruide Li, Samuel Margolis, Jing Wang, Kaidong Wang, Yaran Zhang, Shaolei Wang, Jongchan Park, Charlie Zheng, Lili Yang, Alison Chu, Yuhua Zhang, Liang Gao, Tzung K. Hsiai
  VIEW, 2024 — doi · pubmed
• Multimodal large language model passes specialty board examination and surpasses human test-taker scores: a comparative analysis examining the stepwise impact of model prompting strategies on performance
  Jamil S. Samaan, Samuel Margolis, Nitin Srinivasan, Apoorva Srinivasan, Yee Hui Yeo, Rajsavi Anand, Fadi S. Samaan, James Mirocha, Seyed Amir Ahmad Safavi-Naini, Bara El Kurdi, Ali Soroush, Rabindra Watson, Srinivas Gaddam, Joann G. Elmore, Brennan M.R. Spiegel, Nicholas P. Tatonetti
  medRxiv, 2024 — doi

Conference abstracts

• PROFFi: a phase II randomized controlled study of fisetin and exercise in postmenopausal breast cancer survivors
  Samuel Jacob Margolis, Catherine Crespi, Yuliya Zektser, Arman Niknafs, Nikita V. Baclig, Jingran Ji, Mina Sedrak
  Cancer Research (AACR Annual Meeting abstract CT276), 2026 — doi
• Reporting of patient-reported outcomes in randomized phase 3 clinical trials of FDA-approved medications in breast cancer
  Samuel Jacob Margolis, Andre Naguib Guirguis, Catherine Lee, Saiya Smith, Yuliya Zektser, Arman Niknafs, Jingran Ji, Miriam Silliman, Nikita V. Baclig, Rena Desai Callahan, Kelly Elizabeth McCann, Alexis Ann LeVee, Nicolaos Jay Palaskas, Nicholas Patrick McAndrew, Marla Lipsyc-Sharf, Aashini Master, Patricia A. Ganz, Aditya Bardia, Mina S. Sedrak
  Journal of Clinical Oncology (ASCO abstract e12693), 2026 — doi
• Targeting cellular senescence to enhance skeletal muscle recovery in survivors of breast cancer: an ancillary study of the phase II randomized PROFFi clinical trial
  Jingran Ji, Yuliya Zektser, Marla Lipsyc-Sharf, Alexis Ann LeVee, Rena Desai Callahan, Aashini Master, Kelly Elizabeth McCann, Juan M. Alcantar, Maurice J. Berkowitz, Karo K. Arzoo, Julie Huynh, Lauren Eisenbud, Aditya Bardia, Nicolaos Jay Palaskas, Nicholas Patrick McAndrew, Nikita V. Baclig, Samuel Jacob Margolis, Arman Niknafs, Miriam Silliman, Mina S. Sedrak
  Journal of Clinical Oncology (ASCO abstract TPS12168), 2026 — doi
• Exercise therapy in survivors of gastroesophageal cancer: a phase I, randomized dose-finding study of an individually tailored, remotely supervised exercise intervention
  Jingran Ji, Lee Jones, Sabina Lee, Chaiyaporn Charles Vatanatham, Yuliya Zektser, Nikita V. Baclig, Arman Niknafs, Samuel Jacob Margolis, Sunha Park, Claire Smith, Miriam Silliman, Catherine Lee, Saiya Smith, Karo K. Arzoo, Maurice J. Berkowitz, Mina S. Sedrak
  Journal of Clinical Oncology (ASCO abstract TPS12169), 2026 — doi

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